Contribution of pressure and flow changes to resistance reduction after pulmonary arterial hypertension treatment: a meta-analysis of 3898 patients.
Ioannis T FarmakisAmalia BaroutidouVasiliki PatsiouAlexandra ArvanitakiIoannis DoundoulakisLukas HobohmStefanos ZafeiropoulosStavros V KonstantinidesMichele D'AltoRoberto BadagliaccaGeorge GiannakoulasPublished in: ERJ open research (2024)
Combination therapies, especially with the inclusion of parenteral prostanoids, lead to remarkable haemodynamic improvement in treatment-naïve PAH patients and may unmask the contribution of mPAP reduction to the overall PVR reduction in addition to the increase in CO.