Dopamine Transporter, Age, and Motor Complications in Parkinson's Disease: A Clinical and Single-Photon Emission Computed Tomography Study.

Giovanni PalermoSara GiannoniDaniela FrosiniRiccardo MorgantiDuccio VolterraniUbaldo BonuccelliNicola Pavese Roberto Ceravolo

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

Our findings indicate that a lower dopamine transporter binding in early-onset PD predicts the later development of motor complications, but it is not related to severity of motor symptoms, suggesting age-related differences in striatal compensatory mechanisms in PD. © 2020 International Parkinson and Movement Disorder Society.

Keyphrases

positron emission tomography
computed tomography
early onset
late onset
uric acid
magnetic resonance imaging
dual energy
contrast enhanced
image quality
depressive symptoms
sleep quality
physical activity
dna binding