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Levels of Produced Antibodies after Vaccination with mRNA Vaccine; Effect of Previous Infection with SARS-CoV-2.

Theocharis G KonstantinidisStavroula ZisakiIoannis MitroulisEleni KonstantinidouEftychia G KontekakiGioulia RomanidouAlexandros KarvelasIoanna NanousiLeonidas LazidisDimitrios CassimosChristina TsigalouGeorges MartinisMaria Panopoulou
Published in: Journal of clinical medicine (2021)
The aim of this study was to estimate the immunogenic effect of mRNA vaccine against SARS-CoV-2. This study included 510 participants who received mRNA vaccine. The measurement of anti-COVID-19 antibodies was performed using the Abbott SARS-CoV-2 IgG quantitative assay (Abbott). Overall, mean titer of anti-Spike antibodies was 19,319.2 ± 1787.5 AU/mL. Vaccination induced a robust immunogenic response in those previously infected with SARS-CoV-2 compared with non-infected subjects. Additionally, individuals that were asymptomatic after vaccination produced lower levels of antibodies compared to feverish individuals. In conclusion, remarkably high levels of anti-Spike COVID-19 antibodies were observed after vaccination.
Keyphrases
  • sars cov
  • respiratory syndrome coronavirus
  • coronavirus disease
  • binding protein
  • high throughput
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  • mass spectrometry
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  • single cell