Epigenome-wide association study analysis of calorie restriction in humans, CALERIE TM Trial analysis.

Megan E RamakerDavid L CorcoranAbner T ApsleyMichael S KoborVirginia B KrausWilliam E KrausDavid T S LinMelissa C OrenduffCarl F PieperReem WaziryKim M HuffmanDaniel W Belsky

Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2022)

Although individual CpG site DNAm changes in response to CR were not identified, analyses of sets CpGs identified in prior EWAS revealed CR-induced changes to blood DNAm. Altered CpG sets were enriched for insulin-production, glucose-tolerance, inflammation, and DNA-binding and -regulation pathways, several of which are known to be modified by CR. DNAm changes may contribute to CR effects on aging.

Keyphrases

dna binding
dna methylation
nk cells
type diabetes
oxidative stress
transcription factor
clinical trial
study protocol
diabetic rats
high glucose
phase iii
single cell
metabolic syndrome
drug induced
insulin resistance
glycemic control
open label