In vivo conversion of rat astrocytes into neuronal cells through neural stem cells in injured spinal cord with a single zinc-finger transcription factor.

Masoumeh Zarei-KheirabadiMahdi HesarakiSahar KianiHossein Baharvand

Published in: Stem cell research & therapy (2019)

These results have indicated that the generation of iNSCs or neurons from endogenous astrocytes by in situ reprogramming might be a potential strategy for SCI repair.

Keyphrases

spinal cord
neural stem cells
spinal cord injury
transcription factor
induced apoptosis
cell cycle arrest
neuropathic pain
oxidative stress
endoplasmic reticulum stress
dna binding
cell death
signaling pathway
cerebral ischemia
climate change