Senescence-associated reprogramming induced by interleukin-1 impairs response to EGFR neutralization.

Donatella RomanielloValerio GelfoFederica PaganoEnea FerlizzaMichela SgarziMartina MazzeschiAlessandra MorselliCarmen MianoGabriele D'UvaMattia Lauriola

Published in: Cellular & molecular biology letters (2022)

To sum up, our findings point to the combined blockage of IL-1R and EGFR as a promising therapeutical approach to restore sensitivity to EGFR-targeting monoclonal antibodies.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
dna damage
endothelial cells
cancer therapy