Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia: A MELD study.
Konrad WagstylKirstie WhitakerArmin RaznahanJakob SeidlitzPetra E VértesStephen FoldesZachary HumphreysWenhan HuJiajie MoMarcus LikemanShirin DaviesMatteo LengeNathan T CohenYingying TangShan WangMathilde RipartAswin ChariMartin TisdallNuria BargalloEstefania Conde-BlancoJose Carlos ParienteSaül Pascual-DiazIgnacio Delgado-MartínezCarmen Pérez-EnríquezIlaria LagorioEugenio AbelaNandini MullattiJonathan O'MuircheartaighKaty VecchiatoYawu LiuMaria CaligiuriBen SinclairLucy VivashAnna WillardJothy KandasamyAilsa McLellanDrahoslav SokolMira SemmelrochAne KlosterGiske OpheimClarissa YasudaKai ZhangKhalid HamandiCarmen BarbaRenzo GuerriniWilliam Davis GaillardXiaozhen YouZhong Irene WangSofía González-OrtizMariasavina SeverinoPasquale StrianoDomenico TortoraReetta KalviainenAntonio GambardellaAngelo LabatePatricia DesmondElaine LuiTerry O'BrienJay ShettyGraeme JacksonJohn S DuncanGavin P WinstonLars PinborgFernando CendesJudith Helen CrossTorsten BaldewegSophie AdlerPublished in: Epilepsia (2021)
FCD location is an important determinant of its size, the age at epilepsy onset, and the likelihood of seizure freedom postsurgery. Our atlas of lesion locations can be used to guide the radiological search for subtle lesions in individual patients. Our atlas of regional seizure freedom rates and associated predictive model can be used to estimate individual likelihoods of postsurgical seizure freedom. Data-driven atlases and predictive models are essential for evidence-based, precision medicine and risk counseling in epilepsy.