Primary cervical screening with high risk human papillomavirus testing: observational study.
Matejka ReboljJanet RimmerKarin DentonJohn TidyChristopher MathewsKay EllisJohn SmithChris EvansThomas GilesViki FrewXenia TylerAlexandra SargentJanet ParkerMiles HolbrookKatherine HuntPenny TidburyTanya LevineDavid SmithJulietta PatnickRuth StubbsSue MossHenry KitchenerPublished in: BMJ (Clinical research ed.) (2019)
In England, routine primary hrHPV screening increased the detection of cervical intraepithelial neoplasia grade 3 or worse and cervical cancer by approximately 40% and 30%, respectively, compared with liquid based cytology. The very low incidence of cervical intraepithelial neoplasia grade 3 or worse after three years supports extending the screening interval.