Model-Informed Clinical Development of 6-Monthly Injection of Paliperidone Palmitate in Patients with Schizophrenia: Dosing Strategies Guided by Population Pharmacokinetic Modeling and Simulation (Part II).
Huybrecht T'jollynRaja VenkatasubramanianMartine NeyensSrihari GopalAlberto RussuPartha NandyJuan Jose Perez-RuixoOliver AckaertPublished in: European journal of drug metabolism and pharmacokinetics (2024)
Paliperidone concentration-time profiles after PP6M and PP3M dosing were adequately described by the popPK model. Model-based simulation results provide guidance for clinicians on initiating PP6M therapy, transitioning between paliperidone formulations, the dosing windows to use for maintenance dosing, and managing missed PP6M doses.