The Aβ1-42/Aβ1-40 ratio in CSF is more strongly associated to tau markers and clinical progression than Aβ1-42 alone.
Constance DelabyTeresa EstellésNuole ZhuJavier ArranzIsabel BarroetaMaría Carmona-IraguiIgnacio Illán-GalaMiguel Ángel Santos-SantosMiren AltunaIsabel SalaM Belén Sánchez-SaudinósLaura VidelaSílvia ValldeneuAndrea SubiranaMireia TondoFrancisco Blanco-VacaSylvain LehmannOlivia BelbinRafael BlesaJuan ForteaAlberto LleóDaniel AlcoleaPublished in: Alzheimer's research & therapy (2022)
Although Aβ1-42 and Aβ1-42/Aβ1-40 are considered markers of the same pathophysiological pathway, our findings provide evidence favoring the use of the Aβ1-42/Aβ1-40 ratio in clinical laboratories in the context of AD.
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