SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice.

J LoveSergio A Rodriguez-Aponte Lisa H TostanoskiNeil DalvieRyan JohnstonCatherine Jacob-DolanOlivia PowersNichole P HachmannJessica MillerKevin HallMazuba Siamatu Camille R MazurekNehalee SurveDan H Barouch

Published in: Research square (2023)

We report the direct comparison of monomeric, dimeric and trimeric RBD protein subunit vaccines to a virus-like particle (VLP) displaying RBD. After two and three doses, a RBD dimer and trimer elicited antibody levels in mice comparable to an RBD-VLP. Furthermore, an Omicron (BA.1) RBD hetero-dimer induced neutralizing activity similar to the RBD-VLP. A RBD hetero-dimer and RBD-VLP also shows comparable breadth to other SARS-CoV-2 variants-of-concern (VOCs).

Keyphrases

sars cov
respiratory syndrome coronavirus
gene expression
dna methylation
insulin resistance
high fat diet induced
skeletal muscle
adipose tissue
drug induced
genome wide
diabetic rats