Dihydromyricetin Modulates Nrf2 and NF-κB Crosstalk to Alleviate Methotrexate-Induced Lung Toxicity.

Asmaa I MatoukEman M AwadNashwa Fathy Gamal El-Tahawy Azza A K El-SheikhAliaa Anter

Published in: Pharmaceuticals (Basel, Switzerland) (2023)

This study identified DHM as a promising therapeutic target against MTX-induced pneumonitis via activation of Nrf2 antioxidant signaling while suppressing the NF-κB mediated inflammatory pathways.

Keyphrases

oxidative stress
diabetic rats
signaling pathway
high glucose
lps induced
pi k akt
drug induced
high dose
rheumatoid arthritis
interstitial lung disease
anti inflammatory
toll like receptor