Relationship between human leukocyte antigen alleles and risk of Kaposi's sarcoma in Cameroon.
Elena Maria Cornejo CastroBrian J MorrisonVickie A MarshallNazzarena LaboWendell J MileyNathan ClementsGeorge NelsonPaul NdomKristen StolkaJennifer J Hemingway-FodayMahamat AbassoraXiaojiang GaoJennifer S SmithMary N CarringtonDenise WhitbyPublished in: Genes and immunity (2019)
Several studies published to date report associations between human leukocyte antigen (HLA) alleles and different types of Kaposi's Sarcoma (KS). However, there is little concordance between the HLA alleles identified and the populations studied. To test whether HLA alleles associate with KS in a Cameroonian case-control study, we performed high-resolution HLA typing in KSHV seropositive individuals. Among HIV-positive individuals, carriers of HLA-B*14:01 were at a significantly higher risk of AIDS-KS (p = 0.033). For HIV-negative patients, a gene-wise comparison of allele frequencies identified the HLA-B (p = 0.008) and -DQA1 (p = 0.002) loci as possible risk factors for endemic KS. Our study provides additional understanding of genetic determinants of KS and their implications in disease pathogenesis. Further validation of these findings is needed to define the functional relevance of these associations.
Keyphrases
- hiv positive
- antiretroviral therapy
- men who have sex with men
- endothelial cells
- south africa
- high resolution
- genome wide
- hiv infected
- human immunodeficiency virus
- hiv testing
- hiv aids
- end stage renal disease
- ejection fraction
- newly diagnosed
- prognostic factors
- copy number
- hepatitis c virus
- dna methylation
- patient reported outcomes
- patient reported
- systematic review
- transcription factor
- genome wide association
- clinical evaluation