Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer.

Andreas SeeberFrancesca BattaglinKai ZimmerFlorian KocherYasmine BacaJoanne XiuGilbert SpizzoVeronica Novotny-DiermayrDietmar Rieder Alberto PucciniJeff SwensenMichelle Ellis Richard M GoldbergAxel GrotheyAnthony Frank Shields John L Marshall Benjamin A WeinbergPaul E SacksteinKiat Hon LimGek San TanChadi NabhanWolfgang Michael KornArno AmannZlatko TrajanoskiMartin D Berger Emil LouDominik WolfHeinz-Josef Lenz

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

This is the largest series of RSPOfp/RNF43-mut colorectal cancers reported to date. Comprehensive molecular analyses asserted the unique molecular landscape associated with RSPO/RNF43 and suggested potential alternative strategies to overcome the low clinical impact of Wnt-targeted agents and immunotherapy.

Keyphrases

dna damage response
stem cells
cell proliferation
single molecule
single cell
risk assessment
human health
climate change