Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension.
Jason HongLejla MedzikovicWasila SunBrenda WongGrégoire RuffenachChristopher J RhodesAdam J BrownsteinLloyd L LiangLaila AryanMin LiArjun VadgamaZeyneb KurtTae-Hwi Schwantes-AnElizabeth A MicklerStefan GräfMelanie EyriesKatie A LutzMichael W PauciuloRichard C TrembathFrédéric PerrosI David MontaniNicholas W MorrellFlorent SoubrierMartin R WilkinsWilliam C NicholsMicheala A AldredAnkit A DesaiDavid Alexandre TrégouëtSoban UmarRajan SaggarRichard ChannickRubin M TuderMark W GeraciRobert S StearmanXia YangMansoureh EghbaliPublished in: Circulation (2024)
Our integrative systems biology approach to dissect the PAH lung transcriptome uncovered asporin as a novel protective target with therapeutic potential in PAH.