SOD2 confers anlotinib resistance via regulation of mitochondrial damage in OSCC.

Shuai LiCongyuan CaoZhexun HuangDongxiao TangJie ChenAnxun WangQianting He

Published in: Oral diseases (2022)

SOD2 may be capable of protecting mitochondria by downregulating ROS generation, which contributes to the resistance of anlotinib in OSCC cells. SOD2 can be utilized as a potential therapeutic target to improve the anti-cancer efficacy of anlotinib in OSCC.

Keyphrases

amyotrophic lateral sclerosis
oxidative stress
induced apoptosis
cell death
cell cycle arrest
reactive oxygen species
endoplasmic reticulum stress
signaling pathway
cell proliferation
risk assessment
endoplasmic reticulum
pi k akt