Cerebral cortex and blood transcriptome changes in mouse neonates prenatally exposed to air pollution particulate matter.
Amin HaghaniJason I FeinbergKristy C LewisChristine Ladd-AcostaRichard G JohnsonAndrew E JaffeConstantinos SioutasCaleb E FinchDaniel B CampbellTodd E MorganHeather E VolkPublished in: Journal of neurodevelopmental disorders (2021)
Our findings suggest that prenatal nPM exposure induces transcriptional changes in the cerebral cortex, some of which are also observed in blood. Further research is needed to replicate nPM-induced transcriptional changes with additional biologically relevant time points for brain development.
Keyphrases
- particulate matter
- air pollution
- acute myeloid leukemia
- functional connectivity
- gene expression
- resting state
- subarachnoid hemorrhage
- cerebral ischemia
- transcription factor
- lung function
- high glucose
- pregnant women
- single cell
- white matter
- rna seq
- diabetic rats
- genome wide
- drug induced
- multiple sclerosis
- cystic fibrosis
- low birth weight
- blood brain barrier
- endothelial cells
- preterm birth