iPSC-Derived Astrocytes and Neurons Replicate Brain Gene Expression, Epigenetic, Cell Morphology and Connectivity Alterations Found in Autism.
Hamid Mostafavi AbdolmalekyReza AlamShabnam NohesaraRichard C DethJin-Rong ZhouPublished in: Cells (2024)
Autism-associated expression/epigenetic alterations in iPSC-derived cells replicated those reported in the literature, making them appropriate surrogates to study disease pathogenesis or patient-specific therapeutics.
Keyphrases
- gene expression
- dna methylation
- autism spectrum disorder
- resting state
- intellectual disability
- white matter
- induced apoptosis
- systematic review
- single cell
- cell cycle arrest
- small molecule
- spinal cord
- cell therapy
- induced pluripotent stem cells
- stem cells
- binding protein
- multiple sclerosis
- oxidative stress
- bone marrow
- signaling pathway
- spinal cord injury
- blood brain barrier
- cerebral ischemia
- brain injury