Optogenetic Spreading Depression Elicits Trigeminal Pain and Anxiety Behavior.

Andrea M HarriottDavid Y ChungAylin UnerRefik O BozdayiAndréia Albuquerque Cunha Lopes-de-MoraisTsubasa TakizawaTao QinCenk Ayata

Published in: Annals of neurology (2020)

Altogether, these data show a clinically congruent causal relationship among SD, trigeminal pain, and anxiety behavior, possibly reflecting SD modulation of hypothalamic, thalamic, and limbic mechanisms. ANN NEUROL 2021;89:99-110.

Keyphrases

neuropathic pain
chronic pain
sleep quality
pain management
spinal cord
spinal cord injury
depressive symptoms
electronic health record
deep brain stimulation
data analysis
postoperative pain
neural network