Synergistic anti-tumor activity of miriplatin and radiation through PUMA-mediated apoptosis in hepatocellular carcinoma.

Hironori TanakaKoichi OkamotoYasushi SatoTakahiro TanakaTetsu TomonariFumika NakamuraYasuteru FujinoYasuhiro MitsuiHiroshi MiyamotoNaoki MugurumaAkinori MoritaHitoshi IkushimaTetsuji Takayama

Published in: Journal of gastroenterology (2020)

Miriplatin plus irradiation had synergistic anti-tumor activity on HCC cells through PUMA-mediated apoptosis and cell cycle arrest. This combination may possibly be effective in treating locally advanced HCC.

Keyphrases

cell cycle arrest
cell death
pi k akt
locally advanced
squamous cell carcinoma
cancer therapy
induced apoptosis
rectal cancer
neoadjuvant chemotherapy
signaling pathway
radiation therapy
radiation induced
cell proliferation
oxidative stress
clinical trial
drug delivery
double blind