We synthesized an ultrasensitive probe TP-Golgi for the two-photon ratiometric fluorescence imaging of Golgi polarity. Probe TP-Golgi possesses a large Stokes shift, excellent sensitivity and good selectivity to quantitatively detect environmental polarity. By application of TP-Golgi, we found that the Golgi polarity increased obviously in the kidneys of mice with AKI.
Keyphrases
- fluorescence imaging
- living cells
- quantum dots
- fluorescent probe
- endoplasmic reticulum
- acute kidney injury
- drug induced
- photodynamic therapy
- liver injury
- cardiac surgery
- sensitive detection
- single molecule
- hydrogen peroxide
- type diabetes
- metabolic syndrome
- mass spectrometry
- risk assessment
- label free
- adipose tissue
- adverse drug
- high fat diet induced
- monte carlo
- oxide nanoparticles