Interpretation of Brain Volume Increase in Multiple Sclerosis.
Tomas UherNiels P BergslandJan KrasenskyMichael G DwyerMichaela AndelovaLukas SobisekEva Kubala HavrdovaDana HorakovaRobert ZivadinovManuela VaneckovaPublished in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2020)
BVI occurs in a great proportion of MR scans over short-term follow-up and is not associated with disease stabilization. Although BVI can be caused by several factors, the results indicate that measurement error may contribute to BVI in the majority of cases. Clinicians should be aware of the frequent occurrence of apparent BVI, interpret brain volume changes in MS patients with great caution, and use methods with precise quantification of brain volume changes.