In Vivo Assessment of Astrocyte Reactivity in Patients with Progressive Supranuclear Palsy.

Kosei HirataKiwamu MatsuokaKenji TagaiHironobu EndoHarutsugu TatebeMaiko OnoNaomi KokuboYuko KataokaAsaka OyamaHitoshi ShinotohKeisuke TakahataTakayuki ObataMasoumeh DehghaniJamie NearKazunori KawamuraMing-Rong ZhangHitoshi ShimadaHiroshi ShimizuAkiyoshi KakitaTakanori YokotaTakahiko TokudaMakoto HiguchiYuhei Takado

Published in: Annals of neurology (2024)

We discovered high levels of astrocyte biomarkers in patients with PSP, suggesting astrocyte reactivity. The association between myo-inositol and lactate levels suggests a link between reactive astrocytes and brain energy metabolism changes. Our results indicate that astrocyte reactivity in the anterior cingulate cortex precedes pronounced tau pathology and neurodegenerative processes in that region, and affects brain function in PSP. ANN NEUROL 2024.

Keyphrases

resting state
functional connectivity
white matter
multiple sclerosis