Bone Marrow Adiposity in Premenopausal Women With Type 2 Diabetes With Observations on Peri-Trabecular Adipocytes.
Vicente F C AndradeDébora BesenDomingos C ChulaVictória Z C BorbaDavid DempsterCarolina Aguiar MoreiraPublished in: The Journal of clinical endocrinology and metabolism (2021)
Poor glycemic control is associated with hyperplasia and hypertrophy of BMAs and with lower BV/TV. Ad.N/BS, a new BMA parameter, is correlated with HbA1c and negatively with O.Th. The use of insulin seems to stimulate the expansion of BMA while that of metformin has the opposite effect. These findings suggest that the increase in BMA may play a role in the T2DM bone disease; on the other hand, good glycemic control might help prevent it.
Keyphrases
- glycemic control
- type diabetes
- bone marrow
- bone mineral density
- insulin resistance
- blood glucose
- postmenopausal women
- polycystic ovary syndrome
- adipose tissue
- weight loss
- mesenchymal stem cells
- breast cancer risk
- lipopolysaccharide induced
- lps induced
- metabolic syndrome
- body composition
- pregnancy outcomes
- weight gain
- bone loss
- soft tissue
- cervical cancer screening
- blood pressure
- inflammatory response
- physical activity