Quantitative impact of pre-analytical process on plasma uracil when testing for dihydropyrimidine dehydrogenase deficiency.

Maud MaillardManon Launay Bernard RoyerJérôme GuittonElodie Gautier-VeyretSophie BroutinCamille TronFélicien Le LouedecJoseph CiccoliniDamien RichardHugo AlarcanVincent HaufroidNaïma TafziAntonin SchmittMarie-Christine Etienne-GrimaldiCéline NarjozFabienne Thomasnull null

Published in: British journal of clinical pharmacology (2022)

Caution should be taken when interpreting U concentrations if the time before centrifugation exceeds 1 hour at RT, since it rises significantly afterwards. Not respecting the pre-analytical conditions for DPD phenotyping increases the risk of DPD status misclassification.

Keyphrases

liquid chromatography
blood pressure
high throughput
high resolution
single cell