Examining variation and temporal dynamics of extracellular matrix biomarkers following acute myocardial infarction.
Morgane M Brunton-O'SullivanAna S HolleyGeorgina K BirdGisela A KristonoScott A HardingPeter D LarsenPublished in: Biomarkers in medicine (2022)
Aim: This study investigated an optimal extracellular matrix (ECM) biomarker panel for measurement in acute myocardial infarction (AMI). Materials & methods: Blood samples were collected from 12 healthy volunteers, and from 23 patients during hospital admission (day 1-3) and 6 months following AMI. Protein assays measured: FGFb, MMP-2, -3, -8, -9, osteopontin, periostin, PINP, TGF-β1, TIMP-1, -4 and VEGF. Results: When compared with healthy levels, seven ECM biomarkers were significantly altered in AMI patients, and six of these biomarkers displayed stable expression during hospital admission. Clinical characteristics and baseline cardiac function were not well correlated with ECM biomarkers. Conclusion: We suggest, MMP-2, MMP-3, MMP-8, MMP-9, periostin, PINP and TIMP-1 may be useful ECM biomarkers for future studies in AMI patients.
Keyphrases
- acute myocardial infarction
- extracellular matrix
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- emergency department
- peritoneal dialysis
- healthcare
- percutaneous coronary intervention
- left ventricular
- heart failure
- endothelial cells
- mass spectrometry
- small molecule
- high throughput
- binding protein
- high resolution
- protein protein
- current status