Universal lung epithelium DNA methylation markers for detection of lung damage in liquid biopsies.
Judith MagenheimAriel RokachAyelet PeretzNetanel LoyferGordon CannHamed AminiPatriss MoradiSudharani NagarajuWafa SameerAssaf CohenOphir FogelRottem KuintAvraham AbutbulAiman Abu RmeilehMutaz KaramehPolina Cohen GoichmanOri WaldAmit KorachDaniel NeimanIlana Fox-FisherJoshua MossDaniel CohenSheina PiyanzinRoni Ben AmiAhmad QuteinehEliahu GolombRuth ShemerBenjamin GlaserTommy KaplanZvi G FridlenderYuval DorPublished in: The European respiratory journal (2022)
Universal cfDNA methylation markers of normal lung epithelium allow for mutation-independent, sensitive and specific detection of lung-derived cfDNA, reporting on ongoing lung injury. Such markers can find broad utility in the study of normal and pathologic human lung dynamics.