Temporal Changes in Long-Term Outcomes of Venous Thromboembolism From the Warfarin Era to the Direct Oral Anticoagulant Era.
Kazuhisa KanedaYugo YamashitaTakeshi MorimotoRyuki ChataniYuji NishimotoNobutaka IkedaYohei KobayashiSatoshi IkedaKitae KimMoriaki InokoToru TakaseShuhei TsujiMaki OiTakuma TakadaKazunori OtsuiJiro SakamotoYoshito OgiharaTakeshi InoueShunsuke UsamiPo-Min ChenKiyonori TogiNorimichi KoitabashiSeiichi HiramoriKosuke DoiHiroshi MabuchiYoshiaki TsuyukiKoichiro MurataKensuke TakabayashiHisato NakaiDaisuke SuetaWataru ShioyamaTomohiro DohkeRyusuke NishikawaKoh OnoTakeshi KimuraPublished in: Journal of the American Heart Association (2024)
Along with the shift from warfarin to DOACs, there was a lower risk of recurrent VTE in the DOAC era than in the warfarin era, whereas there was no apparent change in the risk of major bleeding, which might still be an unmet need even in the DOAC era.