Induction of brain-infiltrating T-bet-expressing B cells in multiple sclerosis.

Jamie van LangelaarLiza RijversMalou JanssenAnnet F Wierenga-WolfMarie-José MeliefTheodora A SiepmanHelga E de VriesPeter-Paul A UngerS Marieke van HamRogier Q HintzenMarvin M van Luijn

Published in: Annals of neurology (2019)

This study demonstrates that T-bethigh IgG1+ B cells are triggered by IFNγ and TLR9 signals, likely contributing to enhanced CXCR3-mediated recruitment and local reactivity in the CNS of MS patients. ANN NEUROL 2019;86:264-278.

Keyphrases

multiple sclerosis
end stage renal disease
immune response
ejection fraction
newly diagnosed
white matter
mass spectrometry
prognostic factors
toll like receptor
dendritic cells
inflammatory response
patient reported
nuclear factor