Polymorphisms in the IL-1 gene cluster influence systemic inflammation in patients at risk for acute-on-chronic liver failure.

José Alcaraz-QuilesEsther TitosMireia CasullerasMarco PavesiCristina López-VicarioBibiana RiusAritz LopategiAndrea De GottardiIvo GraziadeiHenning GronbaekPere GinèsMauro BernardiVicente ArroyoJoan Clària

Published in: Hepatology (Baltimore, Md.) (2016)

These data identify two common functional polymorphisms in the IL-1 gene cluster, which are associated with the inflammatory process related to development of ACLF. (Hepatology 2017;65:202-216).

Keyphrases

liver failure
hepatitis b virus
end stage renal disease
ejection fraction
copy number
newly diagnosed
genome wide
chronic kidney disease
peritoneal dialysis
prognostic factors
drug induced
genome wide identification
oxidative stress
big data
machine learning
intensive care unit
transcription factor