A Synergy Between Endotoxin and (1→3)-Beta-D-Glucan Enhanced Neutrophil Extracellular Traps in Candida Administered Dextran Sulfate Solution Induced Colitis in FcGRIIB-/- Lupus Mice, an Impact of Intestinal Fungi in Lupus.
Supichcha SaithongWilasinee SaisornPeerapat VisitchanakunKritsanawan Sae-KhowDirekrit ChiewchengcholAsada LeelahavanichkulPublished in: Journal of inflammation research (2021)
The formation of NETs in Candida-DSS mice was more severe than non-Candida-DSS mice and NETs in Candida-DSS were more profound in FcGRIIB-/- mice than Pristane mice. Prominent NETs in Candida-DSS FcGRIIB-/- mice might be due to the profound responses against LPS+BG in FcGRIIB-/- neutrophils compared with WT cells. These data implied an impact of the inhibitory FcGRIIB in NETs formation and an influence of gut fungi in lupus exacerbation. Hence, gut fungi in a DSS-induced gut-leakage lupus model enhanced colonic NETs that facilitated gut translocation of organismal molecules and synergistically exacerbated lupus activity.
Keyphrases
- systemic lupus erythematosus
- high fat diet induced
- candida albicans
- disease activity
- chronic obstructive pulmonary disease
- rheumatoid arthritis
- insulin resistance
- type diabetes
- metabolic syndrome
- wild type
- intensive care unit
- adipose tissue
- autism spectrum disorder
- anti inflammatory
- early onset
- artificial intelligence
- acute respiratory distress syndrome
- ulcerative colitis
- extracorporeal membrane oxygenation
- data analysis