TMT-Based Quantitative Proteomic Analysis Reveals Downregulation of ITGAL and Syk by the Effects of Cycloastragenol in OVA-Induced Asthmatic Mice.
Xueyi ZhuBaojun LiuZhenhui RuanMengmeng ChenCongcong LiHanlin ShiXi HuangHang YuYaolong ZhouHehua ZhuJing SunYing WeiWeifang XuJing-Cheng DongPublished in: Oxidative medicine and cellular longevity (2022)
These findings suggest that CAG exerts preventive and protective effects on asthma by inhibiting ITGAL, Syk, and the downstream target Vav1.
Keyphrases
- tyrosine kinase
- lung function
- signaling pathway
- chronic obstructive pulmonary disease
- high glucose
- diabetic rats
- cell proliferation
- high resolution
- drug induced
- cystic fibrosis
- air pollution
- allergic rhinitis
- type diabetes
- oxidative stress
- endothelial cells
- label free
- adipose tissue
- mass spectrometry
- wild type
- insulin resistance