Z-Guggulsterone Induces Apoptosis in Gastric Cancer Cells through the Intrinsic Mitochondria-Dependent Pathway.

Ruxi LvMin ZhuKun ChenHaitao XieHongxia Bai Qingfa Chen

Published in: TheScientificWorldJournal (2021)

Inhibition of FXR signaling with z-guggulsterone induced anticancer effects in SGC-7901 cells by decreasing cell proliferation and promoting apoptosis. Z-guggulsterone induced cell apoptosis through the mitochondria-dependent pathway.

Keyphrases

cell proliferation
cell cycle arrest
cell death
diabetic rats
high glucose
induced apoptosis
oxidative stress
endoplasmic reticulum stress
pi k akt
drug induced
reactive oxygen species
cell cycle
endoplasmic reticulum