Dehydroepiandrosterone promotes ovarian angiogenesis and improves ovarian function in a rat model of premature ovarian insufficiency by up-regulating HIF-1α/VEGF signalling.

Yunxiao ZhaoJiawei WangWeili QinQianwen HuJiaxu LiRongyan QinNana MaFengque ZhengWencai TianJinghang JiangJialv HuangAiping Qin

Published in: Reproductive biomedicine online (2024)

DHEA can potentially restore ovarian function in rats with cyclophosphamide-induced POI by up-regulating HIF-1α/VEGF signalling, which promotes the growth of blood vessels in the ovaries.

Keyphrases

endothelial cells
vascular endothelial growth factor
high glucose
low dose
high dose
oxidative stress