Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis.
Ruth J F LoosMarta Guasch-FerréChristina EllervikHassan S DashtiStephen J SharpPeitao WuKim OvervadChloé SarnowskiMikko KuokkanenRozenn N LemaitreAnne E JusticeUlrika EricsonKim V E BraunYuvaraj MahendranAlexis C Frazier-WoodDianjianyi SunAudrey Y ChuToshiko TanakaJian'an LuanJaeyoung HongAnne TjønnelandMing DingAnnamari LundqvistKenneth MukamalRebecca RohdeChristina-Alexandra SchulzOscar H FrancoNiels GrarupYii-Der Ida ChenLydia BazzanoPaul W FranksJulie E BuringClaudia LangenbergChing-Ti LiuTorben HansenMajken K JensenKatri SääksjärviBruce M PsatyKristin L YoungGeorge HindyCamilla Helene SandholtPaul M RidkerJose M OrdovasJames B MeigsOluf PedersenPeter KraftMarkus PerolaKari E NorthMarju Orho-MelanderTrudy VoortmanUlla ToftJerome I RotterLu QiNita G ForouhiDariush MozaffarianThorkild I A SørensenMeir J StampferSatu MännistöElizabeth SelvinFumiaki ImamuraVeikko SalomaaFrank B HuNick J WarehamJosée DupuisCaren E SmithTuomas O KilpeläinenDaniel I ChasmanJose C FlorezPublished in: BMJ (Clinical research ed.) (2019)
These data indicate that genetic burden and the quality of dietary fat are each associated with the incidence of type 2 diabetes. The findings do not support tailoring recommendations on the quality of dietary fat to individual type 2 diabetes genetic risk profiles for the primary prevention of type 2 diabetes, and suggest that dietary fat is associated with the risk of type 2 diabetes across the spectrum of type 2 diabetes genetic risk.