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Iron metabolism in colorectal cancer: a balancing act.

Diogo EstêvãoMiguel da Cruz-RibeiroAna Patrícia CardosoÂngela M CostaMaria José OliveiraTiago L DuarteTânia B da Cruz
Published in: Cellular oncology (Dordrecht) (2023)
This review addresses the complex role of iron in CRC, particularly in what concerns the consequences of iron excess or deprivation in tumor development and progression. We also dissect the regulation of cellular iron metabolism in the CRC microenvironment and emphasize the role of hypoxia and of oxidative stress (e.g. ferroptosis) in CRC. Finally, we underline some iron-related players as potential therapeutic targets against CRC malignancy.
Keyphrases
  • iron deficiency
  • oxidative stress
  • stem cells
  • cell death
  • endothelial cells
  • induced apoptosis
  • heat stress
  • diabetic rats
  • signaling pathway