Clonal Somatic Mutations in Chronic Lung Diseases Are Associated with Reduced Lung Function.
Jeong Hyun YunM A Wasay KhanAuyon J GhoshBrian D HobbsPeter J CastaldiCraig P HershPeter G MillerCarlyne D CoolFrank SciurbaLucas BarwickAndrew H LimperKevin FlahertyGerard J CrinerKevin BrownRobert A WiseFernando J MartinezEdwin K SilvermanDawn DeMeoMichael H ChoAlexander G Bicknull nullPublished in: American journal of respiratory and critical care medicine (2023)
Our identification of an increased prevalence of clonal somatic mutation in diseased lungs that correlates with airway epithelial gene expression and disease severity highlights for the first time the role of somatic mutational processes in lung disease genetics.