Login / Signup

AMPK mediates the neurotoxicity of iron oxide nanoparticles retained in mitochondria or lysosomes.

Hui HuangMengxue ZhouLifo RuanDongqing WangHuiru LuJiayu ZhangJun ChenYi HuZhifang Chai
Published in: Metallomics : integrated biometal science (2020)
Environmental factors may play a critical role in the etiology and pathogenesis of Parkinson's disease (PD). However, the association of PD with specific chemical species remains largely unknown. Here we prepared three kinds of iron oxide nanoparticles and examined their cytotoxicity in a cellular model of PD. We found that lysosome-targeted nanoparticles showed significant cytotoxicity in SH-SY5Y cells. Inhibition of AMPK could aggravate the neurotoxicity of lysosome-targeted nanoparticles as well as mitochondrion-targeted nanoparticles. Alteration of mitochondrial membrane potentials was found to be in agreement with the neurotoxicity of iron nanoparticles. These results suggested an important role of AMPK in regulating iron nanoparticle-associated neurotoxicity.
Keyphrases
  • iron oxide nanoparticles
  • cancer therapy
  • skeletal muscle
  • induced apoptosis
  • oxidative stress
  • walled carbon nanotubes
  • cell death
  • drug delivery
  • cell cycle arrest
  • signaling pathway
  • reactive oxygen species
  • pi k akt