Association of post-operative ctDNA detection with outcomes of patients with early breast cancers.
R CuttsL UlrichM BeaneyM RobertM CoakleyC BunceG W CrestaniS HrebienE KalashnikovaH-T WuS DashnerH SethiA AleshinM LiuA RingA OkinesI E SmithP BarryN C TurnerI Garcia-MurillasPublished in: ESMO open (2024)
In patients with treatment-naive EBC, ctDNA is detectable after surgery. The absence of ctDNA at a single post-surgical timepoint is associated with improved DRFS, supporting the development of future trials studying de-escalation of systemic therapy.