Inflammatory Diseases, Inflammatory Biomarkers, and Alzheimer Disease: An Observational Analysis and Mendelian Randomization.
Jian HuangBowen SuVille KarhunenDipender GillVerena ZuberAri Ahola-OlliSaranya PalaniswamyJuha AuvinenKarl-Heinz HerzigSirkka Keinänen-KiukaanniemiMarko SalmiSirpa JalkanenTerho LehtimäkiVeikko V SalomaaOlli T RaitakariPaul M MatthewsPaul ElliottKonstantinos K TsilidisMarjo-Riitta JarvelinJoanna TzoulakiAbbas DehghanPublished in: Neurology (2022)
Our data suggest that the association between inflammatory diseases and risk of AD is unlikely to be causal and may be a result of confounding. In support, while inflammatory biomarkers showed evidence for causal associations with inflammatory diseases, evidence was weak that they affected both inflammatory disease and AD.
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