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Skeletal Muscle-Derived Irisin Enhances Gemcitabine Sensitivity and Suppresses Migration Ability in Pancreatic Ductal Adenocarcinoma.

Tomoki SugimotoYoshifumi IwagamiShogo KobayashiChihiro YamanakaKazuki SasakiDaisaku YamadaYoshito TomimaruTadafumi AsaokaTakehiro NodaHidenori TakahashiJunzo ShimizuYuichiro DokiHidetoshi Eguchi
Published in: Annals of surgical oncology (2024)
Skeletal muscle-derived irisin may affect PDAC by enhancing its sensitivity to gemcitabine and suppressing EMT.
Keyphrases
  • skeletal muscle
  • insulin resistance
  • signaling pathway
  • epithelial mesenchymal transition
  • locally advanced
  • type diabetes
  • squamous cell carcinoma
  • metabolic syndrome
  • adipose tissue