The circadian regulator Bmal1 in joint mesenchymal cells regulates both joint development and inflammatory arthritis.

Laura E HandSuzanna H DicksonAnthony J FreemontDavid W RayJulie Elizabeth Gibbs

Published in: Arthritis research & therapy (2019)

This study demonstrates the importance of Bmal1 in joint mesenchymal cells in regulating FLS and chondrocyte development. Additionally, we have identified a role for this core clock component for restraining local responses to inflammation and highlight a role for the circadian clock in regulating inflammatory arthritis.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
rheumatoid arthritis
stem cells
bone marrow
endoplasmic reticulum stress
signaling pathway
transcription factor
cell death
cell proliferation