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Circulating 25-hydroxyvitamin D and survival outcomes of colorectal cancer: evidence from population-based prospective cohorts and Mendelian randomisation.

Xiaomeng ZhangYazhou HeXue LiRasha ShraimWei XuLijuan WangSusan M FarringtonHarry CampbellMaria N TimofeevaLina ZgagaPeter Vaughan-ShawEvropi TheodoratouMalcolm G Dunlop
Published in: British journal of cancer (2024)
This study supports the observed association between lower circulating 25-OHD and poorer survival outcomes for CRC patients. Whilst the genotype-specific association between better outcomes and higher 25-OHD is intriguing, we found no support for causality using MR approaches.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • prognostic factors
  • peritoneal dialysis
  • magnetic resonance imaging
  • computed tomography
  • emergency department
  • weight loss