Combined Methylprednisolone Pulse Therapy plus Rituximab for Treating a Rare Juvenile Steroid-Resistant Nephrotic Syndrome with Cerebral Venous Sinus Thrombosis: A Case Report.
Hader I SakrBurhan EdreesHussein Omar TaherTuleen Talal MilianyRaneem Yasser GazzazAsma Omar AlRuwaithiMohammed Fouad AlamerMostafa E MetaweePublished in: Journal of cardiovascular development and disease (2022)
Background : Cerebral venous sinus thrombosis (CVST) secondary to nephrotic syndrome (NS) is rarely reported. Additionally, treating steroid-sensitive nephrotic syndrome (SSNS) that changes to steroid resistance (SRNS) is difficult, with many relapses and side effects. Case presentation : A 32-month-old SSNS male child turned into SRNS and developed cerebral venous sinus thrombosis (CVST), a rare complication of NS. As a result of the administration of combined pulse methylprednisolone and IV Rituximab (RTX) therapy, the patient showed marked improvement, the results of urine analysis were remarkably improved, and the child started to respond to treatment. Conclusion : Successful treatment of a rare case of juvenile SSNS behaving as SRNS with the development of CVST could be established using combined steroid pulse therapy, Enoxaparin, and the B lymphocytes monoclonal antibodies RTX.
Keyphrases
- rare case
- pulmonary embolism
- blood pressure
- subarachnoid hemorrhage
- mental health
- diffuse large b cell lymphoma
- high dose
- case report
- venous thromboembolism
- dengue virus
- cerebral ischemia
- hodgkin lymphoma
- mesenchymal stem cells
- cell therapy
- cerebral blood flow
- zika virus
- bone marrow
- chronic lymphocytic leukemia
- blood brain barrier
- aedes aegypti