Total Synthesis of Scabrolide F.

The first total synthesis of scabrolide F, a norcembranolide isolated from the soft coral <i>Sinularia scabra</i>, is described. Hydroxycarboxylic acid, which is the key synthetic intermediate, was synthesized in a convergent manner by fragment coupling. The obtained hydroxycarboxylic acid was subjected to macrolactonization and subsequent transannular ring-closing metathesis (RCM) to furnish scabrolide F. The synthetic protocol can be extended to the total synthesis of other norcembranolides.