Implications of oxidative stress in the brain plasticity originated by fasting: a BOLD-fMRI study.
Rachida BelaïchSaïd BoujrafMohammed BenzagmoutRabia MagoulMustapha MaaroufiSiham TiznitiPublished in: Nutritional neuroscience (2016)
The maximal BOLD signal changes were calculated for each subject in the motor area M1; Activation maps were calculated and overlaid on the anatomical images. Group analysis of the data was performed, and the average volume and the maximum intensity of BOLD signal in the activated area M1 was determined for all studied volunteers. The current study allowed measuring regional brain volumes and neural network activity before and during an extended period of fasting using BOLD-fMRI. This demonstrated and confirmed the impact of fasting on human brain structure and function. Further studies are required to elucidate mechanisms and enable direct inference of a diet-induced OS effect on the brain.
Keyphrases
- resting state
- functional connectivity
- neural network
- blood glucose
- oxidative stress
- insulin resistance
- deep learning
- resistance training
- high intensity
- blood pressure
- convolutional neural network
- adipose tissue
- electronic health record
- body composition
- big data
- brain injury
- machine learning
- endoplasmic reticulum stress
- heat shock