Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study.
Dae Gyu JangJohn F DouEmily J KoubekSamuel TeenerLili ZhouKelly M BakulskiBhramar MukherjeeStuart A BattermanEva L FeldmanStephen A GoutmanPublished in: Journal of neurology, neurosurgery, and psychiatry (2024)
Metals in plasma and urine associated with increased ALS risk and reduced survival, independent of genetic risk, and correlated with occupational and non-occupational metal exposures. These data underscore the significance of metal exposure in ALS risk and progression.