Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells.

Alexandra Coomans de BrachèneAngela CastelaAnyïshai E MusuayaLorella MarselliPiero MarchettiDecio L Eizirik

Published in: Auto- immunity highlights (2021)

These data suggest that accumulation of endogenous mtdsRNA following degradosome knockdown depends on the proliferative capacity of the cells and is not a mediator of the type I IFN response in human pancreatic beta cells.

Keyphrases

induced apoptosis
cell cycle arrest
endothelial cells
oxidative stress
dendritic cells
cell death
endoplasmic reticulum stress
cell proliferation
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