Potential Perturbations of Critical Cancer-regulatory Genes in Triple-Negative Breast Cancer Cells Within the Humanized Microenvironment of Patient-derived Xenograft Models.
Yujeong HerJihui YunHye-Youn SonWoohang HeoJong-Il KimHyeong-Gon MoonPublished in: Journal of breast cancer (2024)
Humanized PDX models successfully recreated tumor-immune interactions in TNBC. TNFRSF11B, a commonly downregulated gene in humanized PDX models, may play a key role in tumor growth and metastasis. Differential tumor growth rates and gene expression patterns highlighted the complexities of the immune response in the tumor microenvironment of humanized PDX models.
Keyphrases
- gene expression
- monoclonal antibody
- immune response
- stem cells
- induced apoptosis
- genome wide
- dna methylation
- cell cycle arrest
- papillary thyroid
- cell death
- dendritic cells
- young adults
- toll like receptor
- squamous cell
- inflammatory response
- climate change
- lymph node metastasis
- human health
- childhood cancer
- bioinformatics analysis