Melatonin alleviates vascular endothelial cell damage by regulating an autophagy-apoptosis axis in Kawasaki disease.

Yuanzheng ZhengSaihua HuangJialing ZhangJia HouFang WuWenji WangXiao Han Yonghao Gui

Published in: Cell proliferation (2022)

This study revealed that melatonin protects vascular endothelial cells in KD, by suppressing cell apoptosis in an autophagy-dependent manner and reducing the immunopathological damage mediated by macrophages.

Keyphrases

oxidative stress
endothelial cells
endoplasmic reticulum stress
cell death
high glucose
signaling pathway
cell proliferation
vascular endothelial growth factor